WebDec 11, 1996 · A total synthesis of cyclothialidine (1), a new DNA gyrase inhibitor isolated from Streptomyces filipinensis, is described. The synthetic concept was … WebNov 11, 2003 · Concise Synthesis of Cyclothialidine Analogues (VI) with Ring Sizes from 12 to 15: Novel Macrocyclization Protocol Involving Reductive Thiolation. J. Geiwiz, J. Geiwiz. Pharma Div., Chem. Technol., F. Hoffmann-La Roche AG, CH-4070 Basel, Switz. Search for more papers by this author.

cyclothialidine CAS#:147214-63-9 Chemsrc

WebAug 26, 2024 · Cyclothialidine inhibits the ATPase activity of gyrase by competing for the ATP binding site . The precise mode of action of these agents with gyrase is incompletely understood, although ... in what way is zeus connected to the amazons

Total Synthesis of Cyclothialidine - Wiley Online Library

WebAug 15, 2007 · From the SAR around cyclothialidine 2 we know that the introduction of a methoxy and a carboxylic ester group in the meta positions and a lipophilic group (like methyl) in para position to the phenol improves activity. Therefore we coupled the salicylic aldehyde 4a with various anilines to yield the acyclic benzylic amines 5 and the 2,3 … WebAbstract. The DNA gyrase inhibitor cyclothialidine was shown to be an interesting lead structure for the search of new antibacterials. During extensive work elucidating the structure-activity relations, it was demonstrated that variation of the lactone ring size of its bicyclic core was tolerated. Indeed, even ‘ seco ’ analogues exhibited ... WebDescription: Cyclothialidine is a DNA gyrase inhibitor; isolated from Streptomyces filipinensis. Chemical Structure Cyclothialidine CAS# 147214-63-9 Instruction Theoretical Analysis MedKoo Cat#: 596819 … on me beats tyga