Diaphanous related formin 3
WebHere we define a role for the Diaphanous-related formin-3 (DIAPH3) as a non-canonical regulator of metastasis that restrains conversion to amoeboid cell behaviour in multiple cancer types. The DIAPH3 locus is close to RB1, within a narrow consensus region of deletion on chromosome 13q in prostate, breast and hepatocellular carcinomas. WebMay 22, 2005 · Diaphanous-related formins (DRFs) are a subfamily marked by an additional FH3 domain that is required for subcellular localization 4, and two regulatory regions that allow regulation by Rho...
Diaphanous related formin 3
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WebProtein diaphanous homolog 2 is a protein that in humans is encoded by the DIAPH2 gene. [3] [4] Contents 1 Function 2 Interactions 3 References 4 Further reading Function [ edit] This gene may play a role in the development and normal function of the ovaries. Mutations of this gene have been linked to premature ovarian failure. WebJul 1, 2024 · Diaphanous related formin 3 (DIAPH3) promotes tumorigenesis in hepatocellular carcinoma and lung adenocarcinoma, suggesting that DIAPH3 may be a …
WebAug 5, 2024 · study demonstrated the oncogenic activity of DIAPH3 in the progression of hepatocellular carcinoma and suggested that PDIAPH3 might be a therapeutic target. … WebJan 22, 2024 · DIAPH3 diaphanous related formin 3 Gene ID: 81624, updated on 22-Jan-2024 Gene type: protein coding Also known as: AN; DIA2; DRF3; AUNA1; NSDAN; …
WebMar 11, 2024 · DIAPH3 was strongly correlated to tumor immunity cells infiltration, especially MDSC. In addition, the link between DIAPH3 with immunological subtype, molecular subtype, TMB, and MSI were also... WebDIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling Cell Rep. 2024 Jan 10;42 (1):111986. doi: 10.1016/j.celrep.2024.111986. Online ahead of print. Authors
WebIn this study, we identify diaphanous-related formin 3 (DIAPH3), an actin nucleator, as a scaffold protein to initiate liquid-liquid phase separation (LLPS) and form abundant …
WebJul 1, 2024 · Diaphanous related formin 3 knockdown suppresses cell proliferation and metastasis of osteosarcoma cells Diaphanous related formin 3 knockdown suppresses cell proliferation and metastasis of osteosarcoma cells Authors Zehua Zhang # 1 , Fei Dai # 1 , Fei Luo 1 , Wenjie Wu 1 , Shuai Zhang 1 , Rui Zhou 1 , Jianzhong Xu 1 , Qiang Zhou 2 , … paper bags with logo onWebMar 21, 2024 · DIAPH1 (Diaphanous Related Formin 1) is a Protein Coding gene. Diseases associated with DIAPH1 include Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia and Seizures, Cortical Blindness, And Microcephaly Syndrome . Among its related pathways are Signaling by Rho GTPases and RHOC GTPase cycle . paper bags with handles with logoWebAug 19, 2024 · There is a diaphanous autoregulatory domain (DAD) in the C-terminal (Figure 1a); the DID domain binds to the DAD domain in a closed state, leading to an autoinhibited conformation of the formin . DRFs are mainly regulated by Rho GTPases that bind to GBD and DID domains and disrupt the autoregulatory complex [ 17 ] ( Figure 1 b). paper bags with twisted handlesWebThe N terminus consists of a Rho GTPase-binding domain (GBD), which is joint to the formin homology 3 (FH3). DAD can mediate autoinhibition through interactions with the … paper bags with my logoWebFunction [ edit] This gene is a homolog of the Drosophila diaphanous gene and belongs to the protein family of the formins, characterized by the formin homology 2 (FH2) domain. It has been linked to autosomal dominant, fully penetrant, nonsyndromic low-frequency progressive sensorineural hearing loss. paper baking cups wholesaleWebOct 5, 2016 · DIAPH1 encodes human DIA1, a formin protein that elongates unbranched actin. The c.3634+1G>T DIAPH1 mutation causes autosomal dominant nonsyndromic sensorineural hearing loss, DFNA1, characterized by progressive deafness starting in childhood. The mutation occurs near the C-terminus of the diaphanous autoregulatory … paper bags with handles and logoWebDiaphanous-related formin 3 (DIAPH3) has been reported to regulate the motility of cells by remodeling the cytoskeleton. However, the mechanism through which DIAPH3 regulated the motility of cancer cells remains largely unknown. In this study, we have shown that the expression of DIAPH3 was up-regulated in HCC. paper baker creations