WebOct 10, 2024 · To investigate whether PDGF D has any biological functions independent of its ability to activate β-PDGFR possibly via the CUB domain, three arginine residues in the R 340 R 341 GR 343 motif within the GFD, known to be critical for its binding to β-PDGFR, were mutated to alanines (TM). 26 To purify recombinant GFD-D proteins, the CUB domain ... WebIRF-4 was initially characterized in lymphocytes and was shown to function as both a transcriptional repressor and activator. More recently, IRF-4 expression and function have …
JunB regulates homeostasis and suppressive functions of
WebDec 17, 2024 · BATF and IRF4 bind to AP-1-IRF-composite element (AICE) motifs 37, 38, 39, 40, but how BATF and other AP-1 transcription factors regulate IRF4 activity in the eTreg transcriptional program is... WebDec 18, 2009 · The STAT3-binding motif is underlined, IRF4 and IRF8-binding motifs are boxed, and probes #1, #2, and #3 are indicated. (B) EMSAs with nuclear extracts from NFS201 cells treated for 7 hr with 50 ng/ml IL-21. The solid and open arrows indicate IL-21-induced complexes, with the solid arrow corresponding to the STAT3-DNA complex. The … chilly from sml
IRF4 as an Oncogenic Master Transcription Factor
WebMay 24, 2024 · NFKB1 is enriched in module “cyan” for binding motif, target transcripts as well as the corresponding pathway. In the same module, we noticed another TF, IRF4 (with its binding partner BATF), of which the binding motif and the corresponding pathway (IL-17 signaling) are both significantly enriched. WebIRF4 binding to the ISRE motif in the nedd4 gene locus was further confirmed by the conventional ChIP assay, which showed significant enrichment of IRF4 binding at nedd4 gene promoter in... WebDec 18, 2009 · Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo and furthermore revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. chilly friday memes